比较埃索美拉唑和奥美拉唑治疗幽门螺杆菌相关性胃溃疡的临床疗效(1)
【摘要】 目的 分析幽门螺杆菌相关性胃溃疡患者实施埃索美拉唑及奥美拉唑治疗的效果。 方法 64例幽门螺杆菌相关性胃溃疡患者， 根据抽签法随机分为实验组及对照组， 各32例。实验组行埃索美拉唑治疗， 对照组行奥美拉唑治疗。比较两组患者的治疗效果及治疗后幽门螺杆菌根除率， 治疗前后的白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平， 治疗前后的临床症状评分。结果 实验组患者的总有效率为93.75%、治疗后幽门螺杆菌根除率为93.75%， 均高于对照组的75.00%、75.00%， 差异均具有统计学意义 (P<0.05)。治疗前， 两组患者的IL-8、TNF-α水平比较， 差异均无统计学意义(P>0.05);治疗后， 实验组患者的IL-8、TNF-α水平均低于对照组， 差异均具有统计学意义 (P<0.05)。治疗前， 两组患者的腹痛、腹胀、胃灼热、嗳气临床症状评分比较， 差异均无统计学意义(P>0.05);治疗后， 实验组患者的腹痛、腹胀、胃灼热、嗳气临床症状评分均低于对照组， 差异均具有统计学意义(P<0.05)。结论 幽门螺杆菌相关性胃溃疡患者实施埃索美拉唑的疗效更为确切， 明显优于奥美拉唑治疗效果。
【关键词】 幽门螺杆菌相关性胃溃疡;埃索美拉唑;奥美拉唑
DOI：10.14163/j.cnki.11-5547/r.2019.06.038
【Abstract】 Objective To analyze the effect of esomeprazole and omeprazole in the treatment of Helicobacter pylori-associated gastric ulcer. Methods A total of 64 patients with Helicobacter pylori-associated gastric ulcer were divided by lottery methods into experimental group and control group， with 32 cases in each group. The experimental group was treated with esomeprazole， and the control group was treated with omeprazole. Comparison were made on treatment effect， Helicobacter pylori eradication rate after treatment， levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) and clinical symptom scores before and after treatment between the two groups. Results After treatment， the experimental group had total effective rate as 93.75% and Helicobacter pylori eradication rate as 93.75%， which were all higher than 75.00% and 75.00% in the control group， and their difference was statistically significant (P<0.05). Before treatment， both groups had no statistically significant difference in IL-8 and TNF-α level (P>0.05). After treatment， the experimental group had lower IL-8 and TNF-α than the control group， and their difference was statistically significant (P<0.05). Before treatment， both groups had no statistically significant difference in clinical symptoms score of abdominal pain， abdominal distension， heartburn and belching (P>0.05). After treatment， the experimental group had lower linical symptoms score of abdominal pain， abdominal distension， heartburn and belching than the control group， and the difference was statistically significant (P<0.05). Conclusion Esomeprazole is more effective than omeprazole in the treatment of Helicobacter pylori-related gastric ulcer.
【Key words】 Helicobacter pylori-associated gastric ulcer; Esomeprazole; Omeprazole
臨床常见胃溃疡患者， 患病人群以中老年为主， 饮食不节、长期加班人群较为容易诱发幽门螺杆菌相关性胃溃疡， 表现为上腹部疼痛， 病情加重， 可诱发胃穿孔及出血等并发症， 可对患者日常工作及生活造成极大干扰[1]。对幽门螺杆菌相关性胃溃疡患者病因进行分析， 幽门螺杆菌感染发病过程中IL-8、TNF-α发挥了重要作用。临床上主要利用药物治疗幽门螺杆菌相关性胃溃疡患者， 临床上对有效治疗方案进行了大量探讨。本组入组64例幽门螺杆菌相关性胃溃疡患者， 分析实施埃索美拉唑及奥美拉唑治疗的效果， 报告 如下。, 百拇医药(张登清)
【关键词】 幽门螺杆菌相关性胃溃疡;埃索美拉唑;奥美拉唑
DOI：10.14163/j.cnki.11-5547/r.2019.06.038
【Abstract】 Objective To analyze the effect of esomeprazole and omeprazole in the treatment of Helicobacter pylori-associated gastric ulcer. Methods A total of 64 patients with Helicobacter pylori-associated gastric ulcer were divided by lottery methods into experimental group and control group， with 32 cases in each group. The experimental group was treated with esomeprazole， and the control group was treated with omeprazole. Comparison were made on treatment effect， Helicobacter pylori eradication rate after treatment， levels of interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) and clinical symptom scores before and after treatment between the two groups. Results After treatment， the experimental group had total effective rate as 93.75% and Helicobacter pylori eradication rate as 93.75%， which were all higher than 75.00% and 75.00% in the control group， and their difference was statistically significant (P<0.05). Before treatment， both groups had no statistically significant difference in IL-8 and TNF-α level (P>0.05). After treatment， the experimental group had lower IL-8 and TNF-α than the control group， and their difference was statistically significant (P<0.05). Before treatment， both groups had no statistically significant difference in clinical symptoms score of abdominal pain， abdominal distension， heartburn and belching (P>0.05). After treatment， the experimental group had lower linical symptoms score of abdominal pain， abdominal distension， heartburn and belching than the control group， and the difference was statistically significant (P<0.05). Conclusion Esomeprazole is more effective than omeprazole in the treatment of Helicobacter pylori-related gastric ulcer.
【Key words】 Helicobacter pylori-associated gastric ulcer; Esomeprazole; Omeprazole
臨床常见胃溃疡患者， 患病人群以中老年为主， 饮食不节、长期加班人群较为容易诱发幽门螺杆菌相关性胃溃疡， 表现为上腹部疼痛， 病情加重， 可诱发胃穿孔及出血等并发症， 可对患者日常工作及生活造成极大干扰[1]。对幽门螺杆菌相关性胃溃疡患者病因进行分析， 幽门螺杆菌感染发病过程中IL-8、TNF-α发挥了重要作用。临床上主要利用药物治疗幽门螺杆菌相关性胃溃疡患者， 临床上对有效治疗方案进行了大量探讨。本组入组64例幽门螺杆菌相关性胃溃疡患者， 分析实施埃索美拉唑及奥美拉唑治疗的效果， 报告 如下。, 百拇医药(张登清)