阿托伐他汀对冠状动脉瘤样扩张患者C_反应蛋白水平的影响及意义(1)
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【摘要】 目的 探讨阿托伐他汀对冠状动脉瘤样扩张患者血清C反应蛋白水平的影响及意义。方法 30例冠状动脉瘤样扩张患者随机分入阿托伐他汀组及对照组。检测两组患者治疗前后血浆C反应蛋白水平并比较两组的总有效率。结果 两组治疗前后C反应蛋白水平差异有统计学意义(P<0.05)，但阿托伐他汀组较对照组改善更显著(P<0.05)。阿托伐他汀组显效8例，有效5例，无效2例，总有效率86.7%；对照组显效5例，有效5例，无效5例，总有效率66.7%；组间比较差异有统计学意义(P<0.05)。结论 阿托伐他汀可显著降低冠状动脉瘤样扩张患者血浆C反应蛋白水平，改善冠状动脉瘤样扩张患者的预后。
【关键词】阿托伐他汀；冠状动脉瘤样扩张；C-反应蛋白
Effects of atorvastatin on plasma level of Creactive protein in patients with Coronary artery ectasia LIU Jilie. The Cardiology Department of Central Hospital of Luohe,Luohe 462000，China
【Abstract】 Objective
To investigate the effects and roles of atorvastatin on plasma level of Creactive protein in patients with coronary artery ectasia.Methods We studied 30 patients with coronary artery ectasia patients were randomly assigned to atorvastatin group and control group.In the atorvastatin group,the patients received atorvastatin tablets 20 mg.The level of Creactive protein before and after atorvastatin oral administration for 6 months were detected.The total effective rate were investigated between two group. Results The level of plasma Creactive protein of both group were decreased markedly,a significant decreased of plasma Creactive protein level were observed after taking atorvastatin for 6 months (P<0.05). In the atorvastatin group,there were effectual for 8,dffevtive for 5 and ineffective for 2,the total effective rate was 86.7%.In the control group,there were effectual for 5,effective for 5 and ineffective for 5,the total effective rate was 66.7%.A significant increased of the total effective rate were observed in the atorvastatin group compared with that of control group.Conclusion Atorvastatin could effectively decrease the level of plasma Creactive protein and improve the prognosis of the patients with coronary artery ectasia.
【Key words】Atorvaststin; Coronary artery ectasia; Creactive protein
随着冠状动脉介入技术的普遍开展，以心绞痛、急性心肌梗死为主要表现的冠心病患者行冠脉造影却无明显的冠脉狭窄或冠脉急性闭塞，相反却表现为冠脉的局部或弥漫性扩张，即表现为冠状动脉瘤样扩张(coronary artery,CAE)。本研究观察了阿托伐他汀对冠状动脉瘤样扩张患者超敏C反应蛋白水平的影响及意义。
1 资料与方法
1.1 一般资料 选择2006年6月至2010年6月于我科以胸痛为主要临床表现拟诊冠心病但冠脉造影示冠脉未见明显狭窄病变且有CAE现象的患者共30例，其中男20例，女10例，年龄45~69(60.13±6.45)岁，吸烟20例，高血压病23例 ......
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