【摘要】 目的 观察丹红(倍通)注射液的急慢性毒性，对其进行安全性评价。方法 小鼠连续7 d静脉给药，测定药物的半数致死量(LD50)。大鼠连续给药90 d后，处死大部动物，取血，做血常规、血液生化指标测定，取主要脏器称重进行病理学检查。余下大鼠在停药继续喂养2周后，处死进行病理组织学检查。结果 小鼠LD50为39.5 ml /kg。各实验组大鼠在体质量增加、器官系数、血常规、血液生化指标上基本相似，与对照组比较差异无统计学意义(P>0.05)。主要脏器的病理组织学检查未见明显异常。结论 急慢性毒性实验的结果表明该药安全可靠。

    【关键词】 丹红(倍通)注射液；LD₅₀；毒理研究

    The toxicological study of DanhongWANG Bao-zhong,CAO Mao-rong,ZHOU Wei-hong,et al.The Wujing Gereral Hospital of Helong Jiang Province, 150000 China

    【Abstract】 Objective To investigate the acute and chronic toxicity of danhong and evaluate its safety.Methods Mouses were gavargedwith danhongonce a day for seven days.The LD50 was calculated according to the observed dead and alive conditions.Rats were continuously gavarged with danhong for 90 days.After that most of the rats were sacrificed.Blood samples were collected to check conventional blood parameters ......