Abstract： Objective： to analyze the application effect of comfort nursing in the whole nursing of hemodialysis room. Methods： hemodialysis patients who were treated in our hospital from July 2018 to July 2019 were the subjects of this study， and the patients were divided into groups according to the time of admission. Two groups of patients used the same treatment methods， and different nursing methods， the contrast content is the nursing effect of patients. Results： there were 51 (92.72%) patients in the experimental group who fully mastered dialysis knowledge ......