栀子及其活性成分栀子苷防治糖尿病作用机制研究进展(7)
Advance in studies on anti-diabetic mechanism of Gardeniae Fructus and
its active ingredient geniposide
YAO Dong-dong， SHU Luan， YANG Lei， JIA Xiao-bin
(1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica Under State Administration of
Traditional Chinese Medicine， Jiangsu Provincial Academy of Traditional Chinese Medicine， Nanjing 210028， China；
2. Department of Life Science， Anhui University， Hefei 230000， China)
[Abstract] The diabetes is mainly treated by the oral administration of western medicines at present. Despite their rapid curative effect， there have been still many reports for the western medicines about their clinical adverse reactions， failure of effective prevention and treatment of complications and drug resistance. Hence， they are not suitable for long-term administration. Traditional Chinese medicines have a long history in treating diabetes mellitus (DM)， which is commonly known as Xiaokezheng in the theory of traditional Chinese medicines.In recent years， many scholars have taken extracts from traditional Chinese medicines or separated active constituents as the study objects in the expectation of developing new-type drugs for treating and preventing diabetes. Therefore， a large number of study reports have been emerged in this field. Due to their significant glucose-reducing effect and specific effect in treating complications of diabetes， traditional Chinese medicine Gardeniae Fructus and its iridoid component geniposide shall be given full attention. This paper summarized the advance in studies on the curative effect and action mechanism of Gardeniae Fructus and geniposide in preventing and treating diabetes.
[Key words] Gardeniae Fructus； geniposide； diabetes
doi：10.4268/cjcmm20140803
[责任编辑 张宁宁], 百拇医药(姚冬冬 舒娈 杨蕾 贾晓斌)
its active ingredient geniposide
YAO Dong-dong， SHU Luan， YANG Lei， JIA Xiao-bin
(1. Key Laboratory of New Drug Delivery System of Chinese Materia Medica Under State Administration of
Traditional Chinese Medicine， Jiangsu Provincial Academy of Traditional Chinese Medicine， Nanjing 210028， China；
2. Department of Life Science， Anhui University， Hefei 230000， China)
[Abstract] The diabetes is mainly treated by the oral administration of western medicines at present. Despite their rapid curative effect， there have been still many reports for the western medicines about their clinical adverse reactions， failure of effective prevention and treatment of complications and drug resistance. Hence， they are not suitable for long-term administration. Traditional Chinese medicines have a long history in treating diabetes mellitus (DM)， which is commonly known as Xiaokezheng in the theory of traditional Chinese medicines.In recent years， many scholars have taken extracts from traditional Chinese medicines or separated active constituents as the study objects in the expectation of developing new-type drugs for treating and preventing diabetes. Therefore， a large number of study reports have been emerged in this field. Due to their significant glucose-reducing effect and specific effect in treating complications of diabetes， traditional Chinese medicine Gardeniae Fructus and its iridoid component geniposide shall be given full attention. This paper summarized the advance in studies on the curative effect and action mechanism of Gardeniae Fructus and geniposide in preventing and treating diabetes.
[Key words] Gardeniae Fructus； geniposide； diabetes
doi：10.4268/cjcmm20140803
[责任编辑 张宁宁], 百拇医药(姚冬冬 舒娈 杨蕾 贾晓斌)